跨膜蛋白132础抗体
规格：1尘驳/1尘濒
英文名： TMEM132A
别名： GBP; HSPA5-binding protein 1; HSPA5BP1; T132A_HUMAN; Tmem132a; Transmembrane protein 132A.
分子量： 106kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TMEM132A
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
跨膜蛋白132础抗体产物介绍：background: TMEM132A is a 560 amino acid protein encoded by a gene mapping to human chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and ∫ thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated跨膜蛋白132础抗体 with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11. Function: May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation. Subunit: Interacts with HSPA5/GRP78 Subcellular Location: Golgi apparatus membrane; Single-pass type I membrane protein 跨膜蛋白132础抗体(By similarity). Endoplasmic reticulum membrane; Single-pass type I membrane protein Similarity: Belongs to the TMEM132 family. Gene ID: 54972 Database links: Entrez Gene: 540137 Cow Entrez Gene: 612353 Dog Entrez Gene: 100062008 Horse Entrez Gene: 54972 Human Entrez Gene: 98170 Mouse Entrez Gene: 100511308 Pig Entrez Gene: 338474 Rat SwissProt: Q24JP5 Human SwissProt: Q922P8 Mouse SwissProt: Q80WF4 Rat Unigene: 118552 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
跨膜蛋白132础抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 细胞凋亡 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid