G氨基丁酸受体β2+3/GABAA Rβ2+GABAA Rβ2抗体
规格：1尘驳/1尘濒
英文名： GABA A Receptor beta 2 + 3
别名： GABA A receptor beta 3 subunit; GABA alpha receptor beta 2 subunit; GABAA receptor beta 2 subunit; GABAA receptor beta 3 subunit; GABAA receptor subunit beta 2; GABAA receptor subunit beta 3; GABRB2;
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GABA A R
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
G氨基丁酸受体β2+3/GABAA Rβ2+GABAA Rβ2抗体产物介绍：background: Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines. Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepineG氨基丁酸受体β2+3/GABAA Rβ2+GABAA Rβ2抗体 receptor and opening an integral chloride channel. Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). Subcellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Tissue Specificity: Isoform 1 and isoform 2 show reduced expression in schizophrenic brainG氨基丁酸受体β2+3/GABAA Rβ2+GABAA Rβ2抗体. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. Database links: UniProtKB/Swiss-Prot: P47870.2 UniProtKB/Swiss-Prot: P28472.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G氨基丁酸受体β2+3/GABAA Rβ2+GABAA Rβ2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid