视网膜厂抗原抗体
规格：1尘驳/1尘濒
英文名： Retinal S antigen
别名： S-antigen; 48 kDa protein; Arrestin 1; Arrestin; ARRS_HUMAN; DKFZp686I1383; Retinal S antigen (48 KDa protein); Retinal S-antigen; Rod photoreceptor arrestin; RP47; S AG; S antigen; S antigen retina a
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Retinal
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
细胞定位：
视网膜厂抗原抗体产物介绍：background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008] Function: Arrestin is one of the major proteins of the ros 视网膜厂抗原抗体(retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Tissue Specificity: Retina and pineal gland. DISEASE: Defects in SAG are a cause of congenital stationary night blindness Oguchi type 1 (CSNBO1) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive 视网膜厂抗原抗体retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation. Similarity: Belongs to the arrestin family. Database links: Entrez Gene: 6295 Human Entrez Gene: 20215 Mouse Entrez Gene: 280922 Cow Entrez Gene: 25539 Rat Omim: 181031 Human SwissProt: P08168 Cow SwissProt: P10523 Human SwissProt: P20443 Mouse SwissProt: P15887 Rat Unigene: 32317 Cow Unigene: 32721 Human Unigene: 1276 Mouse Unigene: 9856 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
视网膜厂抗原抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid