蛋白质磷酸酶2调节亚基5顿/笔笔2础-叠56-δ抗体
规格：1尘驳/1尘濒
英文名： PPP2R5D
别名： B'delta; Delta isoform of regulatory subunit B56, protein phosphatase 2A; MGC2134; MGC8949; OTTHUMP00000039821; PP2A B subunit B' delta isoform; PP2A B subunit B56 delta isoform; PP2A B subunit PR61 d
分子量： 70kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PPP2R5D
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
蛋白质磷酸酶2调节亚基5顿/笔笔2础-叠56-δ抗体产物介绍：background: In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2A Alpha and PP2A Beta. The PP2A catalytic subunit associates with a variety of regulatory subunits. Regulatory subunits include PP2A-A-Alpha and -A-Beta, PP2A-B-Alpha and蛋白质磷酸酶2调节亚基5顿/笔笔2础-叠56-δ抗体 -B-Beta, PP2A-C-Alpha and -C-Beta, PP2A-B56-Alpha, -B56-Beta, -B56-gamma and -B56-Delta. Function: PPP2R5D is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a蛋白质磷酸酶2调节亚基5顿/笔笔2础-叠56-δ抗体 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. Subcellular Location: Cytoplasmic and nuclear in interphase, nuclear during mitosis Tissue Specificity: Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family. Database links: UniProtKB/Swiss-Prot: Q14738.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白质磷酸酶2调节亚基5顿/笔笔2础-叠56-δ抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid