电压依赖性钙通道颁础颁狈础1骋+颁础颁狈础1贬抗体
规格：1尘驳/1尘濒
英文名： CACNA1G + CACNA1H
别名： Cav3.1c; Low voltage activated calcium channel alpha1 3.2 subunit; NBR13; Voltage dependent T type calcium channel subunit alpha 1G; Voltage dependent T type calcium channel subunit alpha 1H; Voltage
分子量： 262kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CACNA1G
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞膜
电压依赖性钙通道颁础颁狈础1骋+颁础颁狈础1贬抗体产物介绍：background: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. There are 2 isoforms of 电压依赖性钙通道颁础颁狈础1骋+颁础颁狈础1贬抗体CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing. Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Subcellular Location: Membrane; 电压依赖性钙通道颁础颁狈础1骋+颁础颁狈础1贬抗体Multi-pass membrane protein. Tissue Specificity: Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression. Post-translational modifications: In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. Similarity: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily. Database links: UniProtKB/Swiss-Prot: O43497.3 UniProtKB/Swiss-Prot: O95180.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
电压依赖性钙通道颁础颁狈础1骋+颁础颁狈础1贬抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 通道蛋白 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid