瞬时受体电位通道蛋白4抗体
规格：1尘驳/1尘濒
英文名： CABP4
别名： CABP 4; CaBP4; CABP4_HUMAN; Calcium binding protein 4; Calcium-binding protein 4; CSNB 2B; CSNB2B.
分子量： 111kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRPC5
交叉反应：Human, Cow, Sheep,
细胞定位：细胞浆
瞬时受体电位通道蛋白4抗体产物介绍：background: The calcium binding protein (CaBP) family shares much similarity to calmodulin. It has been shown that CaBP proteins can substitute functionally for, and probably augment the function of, calmodulin. Calcium binding proteins are a crucial part of calcium mediated cellular signal transduction in the central nervous system. There are several members of the family with varying expression patterns. CaBP1 and CaBP2 can be expressed as multiple, alternatively spliced variants in brain and retina. CaBP3, CaBP4 and CaBP 5 are restricted to retinal rod and cone cells. Function: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation 瞬时受体电位通道蛋白4抗体and shifting the activation range to more hyperpolarized voltages. Subcellular Location: Cytoplasm. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.Target information above from: UniProt accession P57796 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res. 38:D142-D148 (2010). Information by UniProt瞬时受体电位通道蛋白4抗体 Tissue Specificity: Expressed in retina and in the inner hair cells (IHC) of the cochlea. Post-translational modifications: Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity. DISEASE: Defects in CABP4 are the cause of congenital stationary night blindness type 2B (CSNB2B) [MIM:610427]. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. Similarity: Contains 4 EF-hand domains. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
瞬时受体电位通道蛋白4抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid