周期蛋白结合蛋白抗体
规格：1尘驳/1尘濒
英文名： CACYBP
别名： SIAH Interacting Protein; CACYBP; Calcyclin binding protein; GIG 5; GIG5; Growth inhibiting gene 5; Calcyclin-binding protein; Siah-interacting protein; Growth inhibiting gene 5 protein; hCacyBP; MGC8
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CACYBP/S
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
周期蛋白结合蛋白抗体产物介绍：background: The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: SIAH Interacting Protein may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and 周期蛋白结合蛋白抗体participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. Subunit: Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, 周期蛋白结合蛋白抗体SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1. Subcellular Location: Nucleus. Cytoplasm. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated Post-translational modifications: Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations. Similarity: Contains 1 CS domain. Contains 1 SGS domain. Database links: Entrez Gene: 27101 Human Omim: 606186 Human SwissProt: Q9HB71 Human Unigene: 508524 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
周期蛋白结合蛋白抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞周期蛋白 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid