神经突触相关蛋白厂尝滨罢搁碍4抗体
规格:1尘驳/1尘濒
英文名: SLITRK4
别名: DKFZp547M2010; SLIK4_HUMAN; SLIT and NTRK like family member 4; SLIT and NTRK like protein 4; SLIT and NTRK-like protein 4; Slit and trk like 4 protein; Slit and trk like gene 4; SLITRK 4; SLITRK4.
分子量: 92kDa
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型:笔辞濒测肠濒辞苍补濒
亚型:滨驳骋
纯化方法:affinity purified by Protein A
**原:KLH conjugated synthetic peptide derived from human SLITRK4
交叉反应:Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
细胞定位:细胞膜
神经突触相关蛋白厂尝滨罢搁碍4抗体产物介绍:background: SLITRK family proteins are integral membrane proteins that have a C-terminal domain that is partially similar to TRK neurotrophin receptor proteins and two leucine-rich repeat (LRR) domains that are similar to those of SLIT proteins. SLITRK4 (SLIT and NTRK-like protein 4) is a 837 amino acid single-pass type I membrane protein that contains 18 LRR (leucine-rich) repeats and is expressed in neural tissues, specifically in the thalamus, hypothalamus, subventricular zone, CA3 region of the hippocampus and cortical plate. SLITRK4 may be upregulated in some astrocytic brain tumors such as glioblastomas, astrocytomas and primitive neuroectodermal tumors.神经突触相关蛋白厂尝滨罢搁碍4抗体 As compared with its family member SLITRK2, SLITRK4 only weakly suppresses neurite outgrowth. A study using genome-wide transcriptional profiling suggested that the gene encoding SLITRK4, as well as the ARL5B and PLA2G7 genes, may be involved in the pathogenesis of preeclampsia. Function: Suppresses neurite outgrowth. Subcellular Location: Membrane; Single-pass type I membrane神经突触相关蛋白厂尝滨罢搁碍4抗体 protein Tissue Specificity: Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors. Similarity: Belongs to the SLITRK family. Contains 12 LRR (leucine-rich) repeats. Contains 2 LRRCT domains. Contains 1 LRRNT domain. Database links: UniProtKB/Swiss-Prot: Q8IW52.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经突触相关蛋白厂尝滨罢搁碍4抗体产物应用:ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域:肿瘤 细胞生物 神经生物学 细胞膜蛋白
储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源: Rabbit
外观: Lyophilized or Liquid