神经突触相关蛋白厂尝滨罢搁碍3抗体
规格：1尘驳/1尘濒
英文名： SLITRK3
别名： KIAA0848; SLIT and NTRK like protein 3; SLITRK 3; SLITRK 3; SLIK3_HUMAN.
分子量： 106kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLITRK3
交叉反应：Human, Mouse, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
神经突触相关蛋白厂尝滨罢搁碍3抗体产物介绍：background: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic ?/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. SLITRK3 (SLIT and NTRK-like family, member 3) is a 977 amino acid single-pass type I membrane protein that contains 20 LRR repeats and belongs to the SLITRK family. Expressed at highest levels in cerebral cortex, SLITRK3 is also found in and fetal neural tissues and some astrocytic brain tumors. SLITRK3 functions to suppress neurite outgrowth and plays a role in the regulation of neuronal function. SLITRK3 is encoded by a gene that maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Function: 神经突触相关蛋白厂尝滨罢搁碍3抗体SLITRK3 (SLIT and NTRK-like family 3) is a member of a protein family consisting of six homologous transmembrane proteins (SLITRK1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to SLIT secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of SLITRK3 proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Like every other SLITRK protein except SLITRK1, overexpression of SLITRK3 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth神经突触相关蛋白厂尝滨罢搁碍3抗体. Subcellular Location: Cell Membrane; single pass type I membrane protein Tissue Specificity: Expressed in the occipital lobe of the cerebral cortex of the brain. Expressed at higher levels in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors. Similarity: Belongs to the SLITRK family. Contains 12 LRR (leucine-rich) repeats. Contains 2 LRRCT domains. Contains 1 LRRNT domain. Database links: UniProtKB/Swiss-Prot: O94933.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经突触相关蛋白厂尝滨罢搁碍3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid