12号染色体开放阅读框52抗体
规格：1尘驳/1尘濒
英文名： RITA
别名： C12orf52; Chromosome 12 open reading frame 52; RBPJ-interacting and tubulin-associated protein; RITA; RITA_HUMAN.
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RITA/C12
交叉反应：Human, Cow, Sheep,
细胞定位：细胞核 细胞浆
12号染色体开放阅读框52抗体产物介绍：background: Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I12号染色体开放阅读框52抗体 interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. The C12orf52 gene product has been provisionally designated C12orf52 pending further characterization. Function: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in12号染色体开放阅读框52抗体 neurogenesis. Subunit: Interacts with RBPJ/RBPSUH. Subcellular Location: Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome. Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear. Similarity: Belongs to the RITA family. Database links: Entrez Gene: 84934 Human SwissProt: Q96K30 Human Unigene: 524762 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
12号染色体开放阅读框52抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 信号转导 干细胞 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid