旁瘤抗原惭础1抗体
规格：1尘驳/1尘濒
英文名： PNMA1
别名： 37 kDa neuronal protein; MA1; Paraneoplastic antigen MA1; Neuron- and testis-specific protein 1; Paraneoplastic antigen Ma1; Pnma1; PNMA1_HUMAN.
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PNMA1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
旁瘤抗原惭础1抗体产物介绍：background: Paraneoplastic neurological disorders (PNDs) are rare syndromes that are caused by, or associated with, an underlying neoplasm. The most common neoplasm among young male patients is testicular cancer, but the leading cause among other patients is lung cancer. Most PNDs are caused by an immune response against onconeural antigens, causing progressive neurological damage. The paraneoplastic antigen MA family contains three known members: MA1, MA2 and MA3. MA1, also designated neuron- and testis-specific protein 1, is a nucleolar protein in normal cells but localizes to the cytoplasm of tumor cells. MA2, also designated onconeuronal antigen MA2, is a旁瘤抗原惭础1抗体 nucleolar protein expressed in brain and testis. MA3 is highly expressed in brain and testis and is expressed at low levels in heart, trachea and kidney. Function: PNMA1 (Paraneoplastic antigen MA1) is a protein that is highly restricted to the brain and testis. A paraneoplastic phenomenon is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. These phenomena are mediated by humoral factors (by hormones or cytokines) excreted by tumor cells or by an immune response against the tumor. Sometimes the symptoms of paraneoplastic syndromes show even before the diagnosis of a malignancy. Paraneoplastic syndromes can be divided into 4 main categories: mucocutane paraneoplastic syndromes, neurological paraneoplastic syndromes, haematological paraneoplastic syndromes and endocrine 旁瘤抗原惭础1抗体metabolic syndromes. Subcellular Location: Nucleus; nucleolus. In tumor cells, it is cytoplasmic. Tissue Specificity: Testis and brain specific. In some patients suffering from cancers, it is also specifically expressed by the paraneoplastic tumor cells. Similarity: Belongs to the PNMA family. Gene ID: 9240 Database links: Entrez Gene: 538718 Cow Entrez Gene: 490774 Dog Entrez Gene: 100050444 Horse Entrez Gene: 9240 Human Entrez Gene: 70481 Mouse Entrez Gene: 100154070 Pig Entrez Gene: 170636 Rat Omim: 604010 Human SwissProt: A6QLK5 Cow SwissProt: Q8ND90 Human SwissProt: Q8C1C8 Mouse SwissProt: Q8VHZ4 Rat Unigene: 194709 Human Unigene: 444348. Mouse Unigene: 81186 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
旁瘤抗原惭础1抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid