蛋白酪氨酸磷酸酶受体笔颁笔罢笔1抗体
规格：1尘驳/1尘濒
英文名： PCPTP1
别名： Ch-1PTPase; Ch1 PTPase; DKFZp781C1038; EC PTP; ECPTP; NC PTPCOM1; NC-PTPCOM1; Protein tyrosine phosphatase Cr1PTPase precursor; Protein tyrosine phosphatase NC PTPCOM1; Protein tyrosine phosphatase PC
分子量： 72kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PCPTP1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞浆 细胞膜
蛋白酪氨酸磷酸酶受体笔颁笔罢笔1抗体产物介绍：background: The protein tyrosine phosphatase (PTP) family of proteins are signaling molecules that regulate processes such as cell growth, cell differentiation, oncogenic transformation and the mitotic cycle. PCPTP1, also known as PTPRR (Receptor-type tyrosine-protein phosphatase R), ECPTP, PTPBR7 or PTPRQ, is a 657 amino acid protein that functions to sequester inactive mitogen-activated protein kinases (MAPKs) to the cytoplasm. Expressed primarily in the brain with weaker expression in other parts of the body, PCPTP1 is a receptor-like molecule that is able to dephosphorylate MAPKs, thereby rendering them inactive. Three isoforms of PCPTP1 exist and are蛋白酪氨酸磷酸酶受体笔颁笔罢笔1抗体 designated alpha, beta and gamma. The alpha form is localized to the cell membrane, while the beta and gamma forms are localized to the perinuclear areas within the cytoplasm. Function: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Subunit: Interacts with MAPKs Subcellular Location: 蛋白酪氨酸磷酸酶受体笔颁笔罢笔1抗体Cell membrane and Cytoplasm > perinuclear region. Locates to the perinuclear areas within the cytoplasm. Tissue Specificity: Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. Contains 1 tyrosine-protein phosphatase domain. Database links: UniProtKB/Swiss-Prot: Q15256.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酪氨酸磷酸酶受体笔颁笔罢笔1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞周期蛋白 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid