螺旋转录因子翱罢笔抗体
规格：1尘驳/1尘濒
英文名： OTP
别名： MGC3161; orthopedia homeobox; orthopedia homolog; OTP_HUMAN.
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OTP
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Fruit Fly,
细胞定位：细胞核
螺旋转录因子翱罢笔抗体产物介绍：background: Homeodomain (HD) genes are helix-turn-helix transcription factors that play key roles in the specification of cell fates. OTP (orthopedia homeobox) is a 325 amino acid nuclear protein belonging to the paired homeobox family and Bicoid subfamily. OTP is expressed in neurons, which give rise to the paraventricular (PVN), supraoptic (SON), anterior periventricular (aPV) and arcuate (ARN) nuclei. Containing a homeobox DNA-binding domain and a OAR domain, OTP is suggested to be involved in the differentiation of hypothalamic neuroendocrine cells. At early embryonic stages in mice, the expression of SIM2 is downregulated in the absence of OTP, indicating a potential role 螺旋转录因子翱罢笔抗体for OTP as an upstream regulator of SIM2. OTP is highly conserved in evolution and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Function: OTP is a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may 螺旋转录因子翱罢笔抗体function during brain development. Subcellular Location: Nuclear Similarity: Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: Q5XKR4.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
螺旋转录因子翱罢笔抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid