神经**调控蛋白1抗体
规格：1尘驳/1尘濒
英文名： NPDC1
别名： AI314472; CAB1; Neural proliferation differentiation and control protein 1; NPDC-1; NPDC1; NPDC1_HUMAN.
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NPDC1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
神经**调控蛋白1抗体产物介绍：background: NPDC-1 (Neural Proliferation Differentiation and Control-1) is expressed in neurons once they have stopped dividing and begun to differentiate. NPDC-1 is transported from the Golgi apparatus via vesicles before becoming internalized by endosomes at the cell membrane. NPDC-1 interacts with Cdk2, D-type cyclins, and the transcription factor E2F1. This interaction can lead to an increased replication time, and might have implications in final neural differentiation and apoptosis. NPDC-1 has been shown to神经**调控蛋白1抗体 colocalize with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and Rab3 GEP (Rab3 GTP/GDP exchange protein). One function of NPDC-1 is to regulate retinoic acid-mediated events by directly interacting with retinoid receptors. The amino acid sequence of NPDC-1 is highly conserved between mouse, rat, and human. Function: Suppresses oncogenic transformation in neural and non-neural cells 神经**调控蛋白1抗体and down-regulates neural cell proliferation. Might be involved in transcriptional regulation. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Tissue Specificity: Strongly expressed in brain; especially in hippocampus, frontal lobe and temporal lobe. Similarity: Belongs to the NPDC1/cab-1 family. Database links: UniProtKB/Swiss-Prot: Q9NQX5.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经**调控蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 细胞凋亡 细胞周期蛋白 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid