内皮素转化酶1抗体
规格：1尘驳/1尘濒
英文名： ECE1
别名： ECE 1; ECE-1; Endothelin converting enzyme 1; ECE1_HUMAN.
分子量： 85kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ECE1 C-t
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,
细胞定位：细胞膜
内皮素转化酶1抗体产物介绍：background: The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]. Function: Converts big endothelin-1 to endothelin-1. Subunit: Homodimer; disulfide-linked. Subcellular Location: Cell Membrane. Single pass type II membrane内皮素转化酶1抗体 protein. Tissue Specificity: All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney. DISEASE: Defects in ECE1 are a cause of Hirschsprung disease cardiac defects and autonomic dysfunction (HSCRCDAD)内皮素转化酶1抗体 [MIM:613870]. It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction. Similarity: Belongs to the peptidase M13 family. Gene ID: 1889 Database links: Entrez Gene: 281133 Cow Entrez Gene: 1889 Human Entrez Gene: 230857 Mouse Entrez Gene: 94204 Rat Omim: 600423 Human SwissProt: P42891 Cow SwissProt: P42892 Human SwissProt: Q4PZA2 Mouse SwissProt: P42893 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 内皮素转化酶(endothelin—converting enzyme-1)是内皮素ET生物合成的关键酶，在体内内皮素生物活性调节上起着极为重要的作用。
内皮素转化酶1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid