转录延伸因子狈贰尝贵抗体
规格：1尘驳/1尘濒
英文名： NELF
别名： Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone releasing hormone factor; Nasal embryonic luteinizing hormone-releasing hormone factor; Nelf; NELF_HUMAN.
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NELF
交叉反应：Human, Mouse, Rat, Chicken, Dog, Rabbit,
细胞定位：细胞核 细胞膜
转录延伸因子狈贰尝贵抗体产物介绍：background: NELF-A (negative elongation factor A), NELF-B, NELF-C, NELF-D and NELF-E are components of the NELF complex, which is a a structure that negatively regulates Pol II-dependent transcription elongation. Control of transcription elongation requires a complex interplay between positive transcription elongation factor b (P-TEFb) and negative transcription elongation factors, DSIF and NELF. DSIF and NELF, act as negative transcription elongation factors by increasing the time the polymerase spends at pause sites. 转录延伸因子狈贰尝贵抗体DSIF/NELF inhibition of transcription is prevented by P-TEFb in cooperation with FACT. Function: Couples NMDA receptor signaling to the nucleus. Influences outgrowth of olfactory axons and migration of LHRH neurons. Subunit: Interacts with CABP1 and KPNA1 Subcellular Location: Cell membrane. Nucleus. Found on the outside of the LHRH cell membrane and axons projecting from the olfactory pit and epithelium. Myristoylation is a prerequisite for extranuclear localization. Tissue Specificity: Highly expressed in and fetal brain, testis and kidney.转录延伸因子狈贰尝贵抗体 DISEASE: Defects in NELF may be associated with idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Database links: UniProtKB/Swiss-Prot: Q6X4W1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录延伸因子狈贰尝贵抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid