贵搁础2/贵翱厂尝2抗体
规格：1尘驳/1尘濒
英文名： FRA2
别名： FLJ23306; Fos L2; FOS like antigen 2; Fos related antigen 2; FosL 2; FosL2; FOSL2; FOSL2_HUMAN; FRA 2; fos-related antigen 2.
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FRA2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig,
细胞定位：细胞核
贵搁础2/贵翱厂尝2抗体产物介绍：background: Fos and Jun dimerize to form Activator Protein 1 (AP1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13 acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the贵搁础2/贵翱厂尝2抗体 Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP1 dependent genes. Function: Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in 贵搁础2/贵翱厂尝2抗体PGE2-activated osteoblasts (By similarity). Subunit: Heterodimer Subcellular Location: Nuclear Similarity: Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain. Gene ID: 2355 Database links: Entrez Gene: 2355 Human Entrez Gene: 421416 Chicken Entrez Gene: 14284 Mouse Entrez Gene: 25446 Rat Omim: 601575 Human SwissProt: P18625 Chicken SwissProt: P15408 Human SwissProt: P47930 Mouse SwissProt: P51145 Rat Unigene: 220971 Human Unigene: 596972 Human Unigene: 24684 Mouse Unigene: 10962 Rat Unigene: 163577 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FOSL2蛋白对细胞因子、生长因子、感染或致癌刺激等生理或病理信号发生应答,调节基因的转录, 参与细胞的增殖、分化等过程. FOSL2在肿瘤形成及发展过程中, 通过促进细胞增殖、抑制分化、促进肿瘤细胞的侵袭和转移等过程发挥作用.
贵搁础2/贵翱厂尝2抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid