高密度脂蛋白受体/清道夫受体抗体
规格：1尘驳/1尘濒
英文名： SCARB1/Scavenger Receptor BI
别名： HDL-R; High Density Lipoprotein Receptor; CD36 Antigen like 1; CD36L1; CLA 1; CLA1;SR BI; SRB1; SRBI; Scavenger Receptor BI; CD36 AND LIMPII ANALOGOUS 1; CD36 Antigen like 1; CD36L1; CLA 1; CLA1; Coll
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD36L1
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
高密度脂蛋白受体/清道夫受体抗体产物介绍：background: High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI (Scavenger Receptor BI) protein binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Scavenging Receptor SR-BI plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Function: Receptor for different ligands such高密度脂蛋白受体/清道夫受体抗体 as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. Subunit: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. The C-terminal region binds to PDZK1高密度脂蛋白受体/清道夫受体抗体. Subcellular Location: Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. Tissue Specificity: Widely expressed. Post-translational modifications: N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. Similarity: Belongs to the CD36 family. Gene ID: 949 Database links: Entrez Gene: 949 Human Entrez Gene: 20778 Mouse Entrez Gene: 25073 Rat Omim: 601040 Human SwissProt: Q8WTV0 Human SwissProt: Q61009 Mouse SwissProt: P97943 Rat Unigene: 520348 Human Unigene: 282242 Mouse Unigene: 88169 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 组织细胞中存在多种高密度脂蛋白受体或高密度脂蛋白结合蛋白，这些受体蛋白的组成、结构及一般特征各不相同；高密度脂蛋白受体在脂质代谢中发挥着重要的作用。
高密度脂蛋白受体/清道夫受体抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 生长因子和** 细胞膜受体 糖尿病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid