舞蹈症相关蛋白碍础尝搁狈抗体
规格：1尘驳/1尘濒
英文名： KALRN
别名： Duo; FLJ16443; HAPIP; Huntingtin associated protein interacting protein (duo) ; Huntingtin-associated protein-interacting protein; Kalirin (isoform 2); Kalirin; KALRN ; KALRN_HUMAN ; Protein Duo; RhoG
分子量： 340kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KALRN/Du
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse,
细胞定位：细胞浆
舞蹈症相关蛋白碍础尝搁狈抗体产物介绍：background: HAP1 (huntingtin-associated protein 1) binds to huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a舞蹈症相关蛋白碍础尝搁狈抗体 role in vesicle trafficking and cytoskeletal function. Function: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Subunit: Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton. Tissue Specificity: Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen,舞蹈症相关蛋白碍础尝搁狈抗体amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. Post-translational modifications: Autophosphorylated. DISEASE: Genetic variation in KALRN is associated with susceptibility to coronary heart disease type 5 (CHDS5) [MIM:608901]. CHD is the leading cause of death and disability worldwide. CHD is multifactorial disease with a strong genetic component. Classic epidemiologic studies have revealed many risk factors for CHD, including age, sex, hypertension, dyslipidemia, diabetes mellitus, smoking, and physical inactivity. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 CRAL-TRIO domain. Contains 2 DH (DBL-homology) domains. Contains 1 fibronectin type-III domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 PH domains. Contains 1 protein kinase domain. Contains 2 SH3 domains. Contains 5 spectrin repeats. Database links: Entrez Gene: 8997 Human Entrez Gene: 545156 Mouse Entrez Gene: 84009 Rat Omim: 604605 Human SwissProt: O60229 Human SwissProt: A2CG49 Mouse SwissProt: P97924 Rat Unigene: 8004 Human Unigene: 353103 Mouse Unigene: 450612 Mouse Unigene: 82274 Mouse Unigene: 87882 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
舞蹈症相关蛋白碍础尝搁狈抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 生长因子和** 激酶和磷酸酶 细胞膜受体 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid