鸟嘌呤核苷酸交换因子骋贰贵罢抗体
规格：1尘驳/1尘濒
英文名： GEFT
别名： ARHGEF25; ARHGP_HUMAN; GEFT; p63RhoGEF; Guanine nucleotide exchange factor GEFT; p63RhoGEF ; RAC/CDC42 exchange factor; Rac/Cdc42/Rho exchange factor GEFT; Rho guanine nucleotide exchange factor 25; R
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GEFT
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
鸟嘌呤核苷酸交换因子骋贰贵罢抗体产物介绍：background: GEFT is a 580 amino acid cytoplasmic protein that is highly expressed in excitable tissues such as brain, heart and muscle, and weakly expressed in small intestine, colon, liver, placenta and lung. GEFT may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. GEFT works as a guanine nucleotide exchange factor for the Rho family of small GTPases and links specifically to G alpha q/11-coupled receptors in Rho A activation. 鸟嘌呤核苷酸交换因子骋贰贵罢抗体GEFT is an important regulator of processes involved in axon and dendrite formation. Involved in skeletal myogenesis, GEFT seems to be an exchange factor primarily for Rac 1 in neurons. Existing as two alternatively spliced variants, GEFT contains a DH (DBL-homology) domain and a PH domain. Function: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. Subunit: Interacts (via the DH domain) with BVES (via the C-terminus cytoplasmic tail) 鸟嘌呤核苷酸交换因子骋贰贵罢抗体(By similarity). Interacts with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1. Subcellular Location: Cell membrane. Cytoplasm > myofibril > sarcomere. Highly colocalizes with actin regions. Tissue Specificity: Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Database links: UniProtKB/Swiss-Prot: Q86VW2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鸟嘌呤核苷酸交换因子骋贰贵罢抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid