对接蛋白4抗体
规格：1尘驳/1尘濒
英文名： DOK4
别名： docking protein 4; Downstream of tyrosine kinase 4; FLJ10488; DOK4_HUMAN.
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DOK4
交叉反应：Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
对接蛋白4抗体产物介绍：background: The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in 对接蛋白4抗体the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis. Function: DOK4 (docking protein 4) belongs to the family of docking proteins which interact with receptor tyrosine kinases and mediate particular biological responses. DOK4 functions in RET mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Subunit: Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' (By similarity). Tissue Specificity: Widely expressed. High expression in 对接蛋白4抗体skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells. Post-translational modifications: Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation. Similarity: Belongs to the DOK family. Type B subfamily. Contains 1 IRS-type PTB domain. Contains 1 PH domain. Database links: UniProtKB/Swiss-Prot: Q8TEW6.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
对接蛋白4抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid