二氢嘧啶酶相关蛋白3抗体
规格：1尘驳/1尘濒
英文名： CRMP3
别名： Collapsin response mediator protein 3; CRMP 3; CRMP-3; CRMP3; Dihydropyrimidinase like 4; Dihydropyrimidinase related protein 4; Dihydropyrimidinase-related protein 4; DPYL4_HUMAN; DPYSL4; DRP 4; DRP-
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CRMP3
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞浆
二氢嘧啶酶相关蛋白3抗体产物介绍：background: Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively i二氢嘧啶酶相关蛋白3抗体n the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia. Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration二氢嘧啶酶相关蛋白3抗体. Subcellular Location: Cytoplasm. Tissue Specificity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. Database links: UniProtKB/Swiss-Prot: O14531.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
二氢嘧啶酶相关蛋白3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid