脊索生成素样蛋白1抗体
规格：1尘驳/1尘濒
英文名： CHRDL1
别名： CHL; chordin like 1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT.
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CHRDL1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：分泌型蛋白
脊索生成素样蛋白1抗体产物介绍：background: The patterning of the central nervous system (CNS) relies on the interaction of multiple signaling molecules, including Shh (sonic hedgehog homolog), Wnt proteins and BMPs (bone morphogenetic proteins), with their antagonists, namely chordin and Noggin. Chordin is a key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like BMPs and sequestering them in latent complexes. CHRDL1 (Chordin-like protein 1), also known as CHL, VOPT (Ventroptin) or NRLN1 (Neuralin-1), is a 450 amino acid secreted protein that contains three VWFC domains. Functioning in a similar manner to chordin, CHRDL1 binds to脊索生成素样蛋白1抗体 BMP-4 and prevents the interaction of BMP-4 with its target receptors, thereby antagonizing BMP-4 activity. Additionally, CHRDL1 is thought to play a role in dorsoventral axis formation, embryonic bone formation and angiogenesis, as well as in the differentiation of neural stem cells. Function: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play 脊索生成素样蛋白1抗体an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells. Subcellular Location: Secreted. Tissue Specificity: Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes. Similarity: Contains 3 VWFC domains. Database links: UniProtKB/Swiss-Prot: Q9BU40.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脊索生成素样蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid