表皮生长因子样蛋白2抗体
规格：1尘驳/1尘濒
英文名： CELSR2
别名： Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; CDHF10; CELR2_HUMAN; Celsr2; EGF like domain multip
分子量： 314kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CELSR2
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞膜
表皮生长因子样蛋白2抗体产物介绍：background: Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction. In mouse, CELSR1, CELSR2 and CELSR3 are expressed in the nervous表皮生长因子样蛋白2抗体 system at early developmental stages, and show expression patterns in the developing CNS. CELSR2 is distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells and olfactory neurons. Function: Receptor that may have an important role in cell/cell signaling during nervous system formation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Highest expression in brain and testis. Post-translational modifications: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 表皮生长因子样蛋白2抗体subfamily. Contains 9 cadherin domains. Contains 7 EGF-like domains. Contains 1 GPS domain. Contains 1 laminin EGF-like domain. Contains 2 laminin G-like domains. Database links: UniProtKB/Swiss-Prot: Q9HCU4.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
表皮生长因子样蛋白2抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 通道蛋白 细胞膜受体 G蛋白偶联受体 细胞骨架 细胞外基质 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid