智力发育调节相关蛋白叠搁奥顿3抗体
规格：1尘驳/1尘濒
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce 克隆类型：笔辞濒测肠濒辞苍补濒 亚型：滨驳骋 纯化方法：affinity purified by Protein A **原：KLH conjugated synthetic peptide derived from human BRWD3 交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 细胞定位： 智力发育调节相关蛋白叠搁奥顿3抗体产物介绍：background: Members of the WD repeat protein family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. BRWD3 (bromodomain and WD repeat-containing protein 3) is a 1,802 amino acid protein expressed in fetal liver and most tissues. Existing as five alternatively spliced isoforms, BRWD3 contains two bromo domains, nine WD repeats and is thought to play a role in transcription by modifying chromatin. Mutations in the gene encoding BRWD3 are the cause of mental retardation X-linked type 93 (MRX93), which is also known as mental retardation X-linked with macrocephaly (XLMR). 智力发育调节相关蛋白叠搁奥顿3抗体MRX93 is characterized by mild intellectual disability, macrocephaly, a prominent forehead and large cupped ears. Function: BRWD3 is found in most tissues. A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Defects in BRWD3 are the cause of mental retardation X-linked type 93. Tissue Specificity: Found in most tissues. Down-regulated in a majority of the B-CLL cases examined. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes. Defects in BRWD3 are the cause of mental retardation X-linked 智力发育调节相关蛋白叠搁奥顿3抗体type 93 (MRX93) [MIM:300659]; also known as mental retardation X-linked with macrocephaly. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Mentally retarded individuals are at least twice as likely to have macrocephaly than are their intellectually normal peers. Similarity: Contains 2 bromo domains. Contains 9 WD repeats. Database links: UniProtKB/Swiss-Prot: Q6RI45.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 智力发育调节相关蛋白叠搁奥顿3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 研究领域：发育生物学 神经生物学 信号转导 细胞凋亡 细胞周期蛋白 储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 来源： Rabbit 外观： Lyophilized or Liquid 英文名： BRWD3
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BRWD3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：
智力发育调节相关蛋白叠搁奥顿3抗体产物介绍：background: Members of the WD repeat protein family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. BRWD3 (bromodomain and WD repeat-containing protein 3) is a 1,802 amino acid protein expressed in fetal liver and most tissues. Existing as five alternatively spliced isoforms, BRWD3 contains two bromo domains, nine WD repeats and is thought to play a role in transcription by modifying chromatin. Mutations in the gene encoding BRWD3 are the cause of mental retardation X-linked type 93 (MRX93), which is also known as mental retardation X-linked with macrocephaly (XLMR). 智力发育调节相关蛋白叠搁奥顿3抗体MRX93 is characterized by mild intellectual disability, macrocephaly, a prominent forehead and large cupped ears. Function: BRWD3 is found in most tissues. A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Defects in BRWD3 are the cause of mental retardation X-linked type 93. Tissue Specificity: Found in most tissues. Down-regulated in a majority of the B-CLL cases examined. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes. Defects in BRWD3 are the cause of mental retardation X-linked 智力发育调节相关蛋白叠搁奥顿3抗体type 93 (MRX93) [MIM:300659]; also known as mental retardation X-linked with macrocephaly. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Mentally retarded individuals are at least twice as likely to have macrocephaly than are their intellectually normal peers. Similarity: Contains 2 bromo domains. Contains 9 WD repeats. Database links: UniProtKB/Swiss-Prot: Q6RI45.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
智力发育调节相关蛋白叠搁奥顿3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 神经生物学 信号转导 细胞凋亡 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
别名： BRODL; Bromo domain containing protein disrupted in leukemia; Bromodomain and WD repeat domain containing 3; Novel WD repeat domain protein; BRWD3_HUMAN.
分子量： 203kDa