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脊髓小脑共济失调10抗体

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产物名称: 脊髓小脑共济失调10抗体
产物型号: ATXN10
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

脊髓小脑共济失调10抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。脊髓小脑共济失调10抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


脊髓小脑共济失调10抗体  的详细介绍

脊髓小脑共济失调10抗体

规格:1尘驳/1尘濒

英文名: ATXN10

别名: Ataxin 10; Ataxin-10; ATX10_HUMAN; Atxn10; Brain protein E46 homolog; E46L; FLJ37990; HUMEEP; Like mouse brain protein E46; SCA10; Spinocerebellar ataxia 10; Spinocerebellar ataxia type 10 protein.

分子量: 53kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human ATXN10/S

交叉反应:Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,

细胞定位:细胞浆

脊髓小脑共济失调10抗体产物介绍:background: Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene. Function: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the脊髓小脑共济失调10抗体 Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Subunit: Homooligomer. Interacts with OGT. Interacts with GNB2. Interacts with IQCB1. Subcellular Location: Cytoplasm, perinuclear region. Tissue Specificity: Expressed in the central nervous system. DISEASE: Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10) [MIM:603516]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often 脊髓小脑共济失调10抗体poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA). Similarity: Belongs to the ataxin-10 family. Database links: Entrez Gene: 25814 Human Entrez Gene: 54138 Mouse Omim: 611150 Human SwissProt: Q9UBB4 Human SwissProt: P28658 Mouse SwissProt: Q5RE06 Orangutan Unigene: 475125 Human Unigene: 248906 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

脊髓小脑共济失调10抗体产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  神经生物学  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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