α内磺肽抗体
规格：1尘驳/1尘濒
英文名： ENSA
别名： Alpha endosulfine; ARPP 19e; Endosulfine alpha; ENSA_HUMAN; Alpha-endosulfine; ARPP-19e.
分子量： 13kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ENSA/ARP
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
细胞定位：细胞浆
α内磺肽抗体产物介绍：background: The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, α内磺肽抗体Jul 2008] Function: ENSA (Alpha endosulfine) is expressed in a wide range of tissues including muscle, brain, and endocrine tissues. The recombinant protein inhibits binding of labeled glibenclamide to beta cell membranes. It also inhibits cloned K(ATP) channel currents and thereby stimulates insulin secretion. It was proposed that endosulfine is an endogenous regulator of the K(ATP) channel, which has a key role in the control of insulin release and, more generally, couples cell metabolism to electrical activity. Subunit: Interacts (when phosphorylated at Ser-67) with PPP2R2D. Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109. Subcellular Location: Cytoplasmic Tissue Specificity: Widely expressed α内磺肽抗体with high levels in skeletal muscle and brain and lower levels in the pancreas. Post-translational modifications: Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA. Similarity: Belongs to the endosulfine family. Database links: Entrez Gene: 281142 Cow Entrez Gene: 2029 Human Entrez Gene: 56205 Mouse Entrez Gene: 60334 Rat Omim: 603061 Human SwissProt: O43768 Human SwissProt: P60840 Mouse SwissProt: P60841 Rat Unigene: 632456 Human Unigene: 27154 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
α内磺肽抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 生长因子和** 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid