指甲髌骨综合征相关蛋白狈笔厂1抗体
规格：1尘驳/1尘濒
英文名： LMX1b
别名： LIM homeo box transcription factor 1 beta; LIM homeobox transcription factor 1 beta; LIM homeobox transcription factor 1-beta; LIM-homeobox protein 1.2; LIM/homeobox protein 1.2; LIM/homeobox protein
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LMX1b/NP
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞核
指甲髌骨综合征相关蛋白狈笔厂1抗体产物介绍：background: This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Function: Essential for the specification of dorsal limb fate at both指甲髌骨综合征相关蛋白狈笔厂1抗体 the zeugopodal and autopodal levels. Subcellular Location: Nucleus. Tissue Specificity: Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets. DISEASE: Defects in LMX1B are the cause of nail-patella syndrome (NPS) [MIM:161200]; also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. Database links: Entrez Gene: 4010 Human Entrez Gene: 16917 Mouse Entrez 指甲髌骨综合征相关蛋白狈笔厂1抗体Gene: 114501 Rat GenBank: U77457.1 Human Omim: 602575 Human SwissProt: O60663 Human SwissProt: O88609 Mouse Unigene: 129133 Human Unigene: 39825 Mouse Unigene: 92364 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
指甲髌骨综合征相关蛋白狈笔厂1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid