狈辞驳辞受体反应蛋白抗体
规格：1尘驳/1尘濒
英文名： Lingo-1
别名： FLJ14594; LERN 1; LERN1; Lingo1; Leucine rich repeat and Ig domain containing 1; Leucine rich repeat neuronal protein 1; Leucine rich repeat neuronal protein 6A; Leucine-rich repeat neuronal 6A; Lingo
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Lingo-1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：细胞膜
狈辞驳辞受体反应蛋白抗体产物介绍：background: LINGO-1 (LRR and Ig domain-containing Nogo Receptor interating protein) is a nervous system-specific LRR-Ig-containing protein with an important role in CNS biology. LINGO-1 was discovered in a sequence database search for human SLIT homologs that were selectively expressed in the brain. LINGO-1 is a transmembrane protein that is a component of the Nogo-66 receptor complex. It binds NgR1 and p75 and is an additional functional componenet of the NgR1/p75 signaling complex. Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors.狈辞驳辞受体反应蛋白抗体 Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. Subunit: Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. Post-translational modifications: N-glycosylated. Contains predominantly high-mannose glycans. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 11 LRR (leucine-rich) repeats.狈辞驳辞受体反应蛋白抗体Contains 1 LRRCT domain. Contains 1 LRRNT domain. Contains 1 LRRNT domain Gene ID: 84894 Database links: Entrez Gene: 415344 Chicken Entrez Gene: 84894 Human Entrez Gene: 235402 Mouse Entrez Gene: 315691 Rat Omim: 609791 Human SwissProt: Q50L44 Chicken SwissProt: Q6NUK3 Human SwissProt: Q96FE5 Human SwissProt: Q9D1T0 Mouse Unigene: 656765 Human Unigene: 246605 Mouse Unigene: 20269 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经生物学相关蛋白（Neurobiology） LINGO-1是一种体内体外少突胶质细胞(Oligodendrocyte)分化和髓鞘(myelination)的负调控因子，神经元上的LINGO-1被证明参与调节**神经再生的抑制信号，而少突胶质细胞表达的LINGO-1分子参与负调节少突胶质细胞的髓鞘化过程，是一种体内体外少突胶质细胞(Oligodendrocyte)分化和髓鞘(myelination)的负调控因子。
狈辞驳辞受体反应蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 神经生物学 信号转导 通道蛋白 细胞膜受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid