谷氨酰胺转胺酶6抗体
规格：1尘驳/1尘濒
英文名： Transglutaminase 6
别名： TGase6; Protein-glutamine gamma-glutamyltransferase 6; TG6; TGase Y; TGase-3-like; TGase-6; TGM3L_HUMAN; TGM6; TGY; Transglutaminase Y; Transglutaminase-3-like; Transglutaminase-6.
分子量： 79kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TGase6/T
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：
谷氨酰胺转胺酶6抗体产物介绍：background: Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane, known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through the formation of disulfide bonds and gamma-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are Ca2+-dependent enzymes, which catalyze the formation of isopeptide bonds by transferring an amine to a glutaminyl residue, thereby cross-linking glutamine residues and lysine residues in substrate proteins. T谷氨酰胺转胺酶6抗体Gases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. TGase6 (transglutaminase 6), also known as TGM6, TGY or TGM3L, is a 706 amino acid protein that catalyzes the cross-linking of proteins and the conjugation of proteins to polyamines. As a result of alternative splicing, two TGase6 isoforms exist. Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. DISEASE: Defects in TGM6 are the cause of spinocerebellar ataxia type 35 (SCA35) [MIM:613908]. A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum 谷氨酰胺转胺酶6抗体with variable involvement of the brainstem and spinal cord. SCA35 patients commonly show upper limb involvement and torticollis. There is no cognitive impairment. Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. Database links: Entrez Gene: 343641 Human Entrez Gene: 241636 Mouse Entrez Gene: 296152 Rat Omim: 613900 Human SwissProt: O95932 Human Unigene: 452039 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷氨酰胺转胺酶6抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞凋亡 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid