突触结合蛋白14抗体
规格：1尘驳/1尘濒
英文名： Synaptotagmin-14
别名： Synaptotagmin14; Synaptotagmin 14; SCAR11; Synaptotagmin XIV; Synaptotagmin-14; SYT14; SYT14_HUMAN; SytXIV.
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Synaptot
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
突触结合蛋白14抗体产物介绍：background: Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Synaptotagmin XIV, also known as SytXIV, is a 555 amino acid single-pass type III membrane protein belonging to the Synaptotagmin family. With the ability to form heterodimers, Synaptotagmin XIV mainly exists as a homodimer and contains two C2 突触结合蛋白14抗体domains, an N-terminal transmembrane domain and a putative fatty-acylation site. Synaptotagmin XIV is Ca2+-independent and may function in the trafficking and exocytosis of secretory vesicles to tissues outside the brain. Disruption of Synaptotagmin XIV may be affiliated with neurodevelopmental abnormalities. Synaptotagmin XIV exists as six alternatively spliced isoforms and is encoded by a gene on human chromosome 1q32.2. Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Subunit: Homodimer. Can also form heterodimers Subcellular Location: Membrane; Single-pass type III membraneprotein. Note=Localized in perinuclear and submembranous突触结合蛋白14抗体regions. Tissue Specificity: Highly expressed in fetal and braintissue. DISEASE: Defects in SYT14 are the cause of spinocerebellar ataxiaautosomal recessive type 11 (SCAR11) [MIM:614229]. Spinocerebellarataxia is a clinically and genetically heterogeneous group ofcerebellar disorders. Patients show progressive incoordination ofgait and often poor coordination of hands, speech and eyemovements, due to degeneration of the cerebellum with variableinvolvement of the brainstem and spinal cord. SCAR11 is associatedwith psychomotor retardation. Similarity: Belongs to the synaptotagmin family. Contains 2 C2 domains. Database links: UniProtKB/Swiss-Prot: Q8NB59.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
突触结合蛋白14抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid