嘌呤核苷磷酸化酶抗体
规格：1尘驳/1尘濒
英文名： Nucleoside phosphorylase
别名： Inosine phosphorylase; MGC117396; MGC125915; MGC125916; NP; Np1; Nucleoside phosphorylase; PNP; Pnp1; PNPH_HUMAN; PRO1837; PUNP; Purine nucleoside orthophosphate ribosyltransferase; Purine nucleoside
分子量： 32kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PNP/Nucl
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
嘌呤核苷磷酸化酶抗体产物介绍：background: Purine nucleoside phosphorylase (PNP), also designated inosine phosphorylase, forms a homotrimer. It belongs to the PNP/MTAP phosphorylase family of proteins. Human PNP catalyzes the reversible phosphorolysis of ribonucleosides and 2’-deoxyribonucleosides with specificity for guanine, hypoxanthine, and their analogs. PNP deficiency is a rare autosomal recessive genetic disease associated with a severe defect in T-lymphocyte function and neurologic disorder in children, comprising four percent of combined immunodeficiency cases. Children with PNP deficiency are highly prone to infections, autoimmune disorders, neurological 嘌呤核苷磷酸化酶抗体impairment, and cancer. Function: Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNP deficiency) [MIM:613179]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children. Subunit: Homotrimer. Subcellular Location: Cytoplasm, cytoskeleton (By similarity).Cytoplasm Tissue Specificity: Expressed in red blood cells; overexpressed inred blood cells (cytoplasm) of嘌呤核苷磷酸化酶抗体 patients with hereditarynon-spherocytic hemolytic anemia of unknown etiology. DISEASE: Defects in PNP are the cause of purine nucleosidephosphorylase deficiency (PNPD) [MIM:613179]. It leads to a severeT-cell immunodeficiency with neurologic disorder in children. Similarity: Belongs to the PNP/MTAP phosphorylase family. Database links: Entrez Gene: 4860 Human Omim: 164050 Human SwissProt: P00491 Human Unigene: 75514 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
嘌呤核苷磷酸化酶抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 **细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid