朊蛋白顿笔尝抗体
规格：1尘驳/1尘濒
英文名： Doppel
别名： DPL; Dublet; MGC41841; Prion gene complex downstream; Prion like protein doppel; Prion protein 2 (dublet); Prion protein 2; Prion-like protein doppel; PRND; PRND_HUMAN; PrPLP.
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Doppe1 (
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：细胞膜
朊蛋白顿笔尝抗体产物介绍：background: Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, including scrapie in sheep, BSE in cattle, and Cruetzfeldt-Jacob disease in humans. 朊蛋白顿笔尝抗体The PRND gene locus, located on human chromosome 20p, encodes for the doppel protein (Dpl), which exhibits approximately 25% sequence homology with PrP. Dpl is characterized by an alpha-helical conformation, intramolecular disulfide bonds, and two N-linked oligosaccharides, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor. Dpl is highly expressed in testis and heart and is detectable in the brain of neonatal mice. Dpl does not appear to contribute to prion disease progression, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice. Dpl is also thought to play a role in angiogenesis, specifically maturation of the blood-brain barrier. 朊蛋白顿笔尝抗体Subcellular Location: ell membrane; Lipid-anchor, GPI-anchor Tissue Specificity: Expressed in testis. Similarity: Belongs to the prion family. Database links: Entrez Gene: 23627 Human Entrez Gene: 26434 Mouse Entrez Gene: 113910 Rat Omim: 604263 Human SwissProt: Q9UKY0 Human SwissProt: Q9QUG3 Mouse Unigene: 406696 Human Unigene: 180750 Mouse Unigene: 94278 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
朊蛋白顿笔尝抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 **及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid