膜粘连蛋白 I抗体
规格：1尘驳/1尘濒
英文名： Annexin I
别名： Annexin I; AnnexinI; Annexin I (lipocortin I); Annexin 1; Annexin-1; Annexin1; AnnexinA1; Annexin A1; AnnexinI; ANX 1; ANX A1; ANX1; ANXA 1; ANXA1; ANXA1 protein; Calpactin 2; Calpactin II; CalpactinI
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Annexin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞膜
膜粘连蛋白 I抗体产物介绍：background: This gene encodes a protein that belongs to a family of Ca(2+) dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti inflammatory activity. Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity. Subunit: Homodimer in placenta (20%);膜粘连蛋白 I抗体 linked by transglutamylation. Interacts with DYSF (By similarity). Subcellular Location: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity). Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity). Post-translational modifications: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in 膜粘连蛋白 I抗体loss of the inhibitory activity. Similarity: Belongs to the annexin family. Contains 4 annexin repeats. Gene ID: 301 Database links: Entrez Gene: 301 Human Entrez Gene: 16952 Mouse Entrez Gene: 25380 Rat Omim: 151690 Human SwissProt: P04083 Human SwissProt: P10107 Mouse SwissProt: P07150 Rat Unigene: 494173 Human Unigene: 248360 Mouse Unigene: 1792 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Annexin 1是一种分子量为35～36KD的Ca2+依赖性磷脂结合蛋白，能与PS高亲和力特异性结合。 钙依赖性磷脂结合蛋白其意义：检测早期凋亡的细胞，同时可区分活细胞和坏死细胞磷脂酰丝氨酸（Phosphatidylserine，PS）正常位于细胞膜的内侧，但在细胞凋亡的早期，PS可从细胞膜的内侧翻转到细胞膜的表面，暴露在细胞外环境中.
膜粘连蛋白 I抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid