细胞骨架相关蛋白1/微管蛋白折迭辅助因子叠抗体
规格：1尘驳/1尘濒
英文名： CKAP1
别名： TBCB; CG22; CKAPI; Cytoskeleton associated protein 1; Cytoskeleton associated protein CKAPI; Cytoskeleton-associated protein 1; Cytoskeleton-associated protein CKAPI; TBCB_HUMAN; Tubulin folding cofac
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CKAP1 (1
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞浆
细胞骨架相关蛋白1/微管蛋白折迭辅助因子叠抗体产物介绍：background: Microtubules, the primary component of the cytoskeletal network, are highly dynamic structures composed of Alpha/Beta Tubulin heterodimers. Biosynthesis of functional microtubules involve the participation of several chaperones, termed Tubulin folding cofactors A (TBCA), B (TBCB), D (TBCD), E (TBCE) and C (TBCC), that act on folding intermediates downstream of the cytosolic chaperon, alternatively named TCP. TBCB (tubulin folding cofactor B), also known as CG22, CKAP1 or CKAPI, is a 244 amino acid cytoplasmic protein containing one CAP-Gly domain and in widely expressed. TBCB is involved in the regulation of tubulin heterodimer dissociation and may function as a negative regulator of axonal growth. Function: Binds to alpha-tubulin folding intermediates after their interaction 细胞骨架相关蛋白1/微管蛋白折迭辅助因子叠抗体with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. Subunit: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. Binds to GAN. Subcellular Location: Cytoplasm. Cytoplasm > cytoskeleton. Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates 细胞骨架相关蛋白1/微管蛋白折迭辅助因子叠抗体at the growth cone. Tissue Specificity: Found in most tissues. Post-translational modifications: Phosphorylation by PAK1 is required for normal function. Phosphorylated upon DNA damage, probably by ATM or ATR. Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome. Similarity: Belongs to the TBCB family. Contains 1 CAP-Gly domain. Database links: Entrez Gene: 1155 Human Entrez Gene: 66411 Mouse Entrez Gene: 292777 Rat Omim: 601303 Human SwissProt: Q99426 Human SwissProt: Q9D1E6 Mouse Unigene: 31053 Human Unigene: 27947 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞骨架相关蛋白1/微管蛋白折迭辅助因子叠抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid