δ-连环蛋白抗体
规格：1尘驳/1尘濒
英文名： delta 2 Catenin
别名： Catenin (cadherin associated protein) delta 2; Catenin delta 2; Catenin delta-2; CTND2_HUMAN; CTNND 2; CTNND2; Delta catenin; Delta-catenin; GT 24; GT24; Neural plakophilin related arm repeat protein;
分子量： 133kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human delta 2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
细胞定位：细胞核
δ-连环蛋白抗体产物介绍：background: The Alpha-, Beta-, Gamma-, and Delta -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Alpha-catenin interacts with E-cadherin associated protein and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. Beta-catenin also complexes with the tumor suppressor protein APC. Gamma-catenin, also known as plakoglobin, is a protein that binds ?catenin and N-cadherin. Gamma-catenin interacts with presenilin 1 and is expressed in the brain. The gene encoding Gamma-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding Gamma-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. In addition,δ-连环蛋白抗体 the transmembrane phosphatase PTPm associates with catenin/ cadherin complexes and may regulate complex signaling. Function: Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Subunit: Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with ARHGEF28. Interacts (via the extreme C-terminus) withδ-连环蛋白抗体 FRMPD2 (via the PDZ 2 domain). Subcellular Location: Nucleus. Tissue Specificity: Predominantly expressed in brain. Post-translational modifications: O-glycosylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the beta-catenin family. Contains 9 ARM repeats. Database links: Entrez Gene: 1501 Human Entrez Gene: 114028 Rat Omim: 604275 Human SwissProt: Q9UQB3 Human SwissProt: O35116 Rat Unigene: 314543 Human Unigene: 15163 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
δ-连环蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 干细胞 细胞骨架 细胞外基质 表观遗传学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid