视神经细胞相关蛋白/早老素结合蛋白抗体
规格：1尘驳/1尘濒
英文名： DOCK3
别名： Dedicator of cytokinesis protein 3; DOCK 3; MOCA; Modifier of cell adhesion; Presenilin binding protein; DOCK3_HUMAN.
分子量： 233kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DOCK3 (1
交叉反应：Human, Mouse, Rat, Dog, Pig, Rabbit,
细胞定位：细胞浆
视神经细胞相关蛋白/早老素结合蛋白抗体产物介绍：background: MOCA (modifier of cell adhesion), also known as Presenilin-binding protein (PBP) or dedicator of cytokinesis protein 3 (DOCK3), is a 2030 amino acid cytoplasmic protein belonging to the DOCK family. MOCA interacts with Presenilin proteins and has the ability to stimulate Tau phosphorylation suggesting that MOCA may be involved in Alzheimer disease. MOCA is also thought to be a guanine nucleotide exchange factor (GEF) which activates small GTPases by exchanging bound GDP for free GTP. Analysis of ectopic expression suggests that MOCA may affect the function of small GTPases involved in the regulation of Actin cytoskeleton or cell adhesion receptors. MOCA is localized to the neuropil, and sometimes in pyramidal cells, in normal brains, while in Alzheimer disease brains, MOCA is present in neurofibrillary tangles. Function: DOCK3 is a potential Guanine Nucleotide Exchange factor, present predominantly in brain. DOCK3 is localised in the视神经细胞相关蛋白/早老素结合蛋白抗体 neuropil and occasionally in the pyramidal cells. In brains of patients with Alzheimer's disease, it is associated with neurofibrillary tangles. DOCK3 may be required for maintaining the functional integrity of axons and loss of DOCK3 may result in axonal degeneration. It is associated with behavioural/developmental conditions like Attention Deficit Hyperactivity disorder. Subunit: Interacts with presenilin proteins PSEN1 and PSEN2. Interacts with CRK Subcellular Location: Cytoplasmic Tissue Specificity: In normal brains, it is localized in the neuropil,视神经细胞相关蛋白/早老素结合蛋白抗体and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles. [DOMAIN] The DHR-2 domain may mediate some GEF activity DISEASE: Note=A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9. Similarity: Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Contains 1 SH3 domain. Database links: UniProtKB/Swiss-Prot: Q8IZD9.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
视神经细胞相关蛋白/早老素结合蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 干细胞 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid