短蛋白聚糖抗体
规格：1尘驳/1尘濒
英文名： Aggrecan
别名： Brevican; Aggrecan; BCAN; BEHAB; Brain enriched hyaluronan binding protein; Brevican core protein; Brevican core protein isoform 1; Brevican core protein isoform 2; Brevican proteoglycan; Chondroitin
分子量： 99kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Brevican
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜 细胞外基质 分泌型蛋白
短蛋白聚糖抗体产物介绍：background: This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008] Function: Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. 短蛋白聚糖抗体It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C-terminal epitope EAMESE. Subunit: Interacts with TNR Subcellular Location: Isoform 1 is secreted, extracellular space, extracellular短蛋白聚糖抗体 matrix; Isoform 2 is found on the membrane; Lipid-anchor, GPI-anchor. Post-translational modifications: Contains mostly chondroitin sulfate. O-glycosylated with a core 1 or possibly core 8 glycan. Similarity: Belongs to the aggrecan/versican proteoglycan family. Contains 1 C-type lectin domain. Contains 1 EGF-like domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 2 Link domains. Contains 1 Sushi (CCP/SCR) domain. Database links: Entrez Gene: 176 Human Entrez Gene: 11595 Mouse Entrez Gene: 58968 Rat Entrez Gene: 403828 Dog Omim: 155760 Human SwissProt: Q28343 Dog SwissProt: P16112 Human SwissProt: Q61282 Mouse SwissProt: P07897 Rat Unigene: 2159 Human Unigene: 358571 Mouse Unigene: 54503 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
短蛋白聚糖抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞粘附分子 细胞骨架 细胞外基质 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid