环化核苷酸调控阳离子通道蛋白亚型2/4抗体
规格：1尘驳/1尘濒
英文名： HCN2 + HCN4
别名： HCN2+HCN4; HCN2 / HCN4; HCN2+4; HCN2/4; BCNG 2; Brain cyclic nucleotide gated channel 2; HAC 1; HCN 4; HCN 2; Hyperpolarization activated cyclic nucleotide gated potassium channel 4;HCN2_HUMAN; HCN4_H
分子量： 97+129kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HCN2 + H
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞膜
环化核苷酸调控阳离子通道蛋白亚型2/4抗体产物介绍：background: Hyperpolarization activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting 环化核苷酸调控阳离子通道蛋白亚型2/4抗体potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node. Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2 Subcellular Location: Membrane; Multi pass membrane protein. Tissue Specificity: Highly expressed throughout the brain. Detected at 环化核苷酸调控阳离子通道蛋白亚型2/4抗体low levels in heart. Similarity: Belongs to the potassium channel HCN family. Contains 1 cyclic nucleotide-binding domain. Database links: Entrez Gene: 10021 Human Entrez Gene: 610 Human Entrez Gene: 15166 Mouse Entrez Gene: 330953 Mouse Entrez Gene: 114244 Rat Entrez Gene: 59266 Rat Omim: 602781 Human Omim: 605206 Human SwissProt: Q9UL51 Human SwissProt: Q9Y3Q4 Human SwissProt: O70507 Mouse SwissProt: O88703 Mouse SwissProt: Q9JKA7 Rat SwissProt: Q9JKA9 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环化核苷酸调控阳离子通道蛋白亚型2/4抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 神经生物学 信号转导 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid