促代谢型谷氨酸受体2抗体
规格：1尘驳/1尘濒
英文名： Metabotropic glutamate receptor 2
别名： Metabotropic Glutamate Receptor 2; Glutamate Receptor Metabotropic 2; Gprc1b; AMPA selective glutamate receptor 2; GLUR 2; GLUR2; GLURB; Glutamate receptor metabotropic 2; Metabotropic Glutamate Recep
分子量： 96kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRM2
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse,
细胞定位：细胞膜
促代谢型谷氨酸受体2抗体产物介绍：background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist 促代谢型谷氨酸受体2抗体selectivities. Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Subunit: Interacts with GRASP. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in different regions of the brain as well as in fetal brain. Similarity: Belongs to the G-protein coupled receptor 3 family. Gene ID: 2912 Database links: Entrez Gene: 2912 Human促代谢型谷氨酸受体2抗体 Entrez Gene: 108068 Mouse Entrez Gene: 24415 Rat Omim: 604099 Human SwissProt: Q14416 Human SwissProt: Q14BI2 Mouse SwissProt: P31421 Rat Unigene: 121510 Human Unigene: 410822 Mouse Unigene: 424639 Mouse Unigene: 9681 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 谷氨酸受体-代谢能2；主要参与细胞信号转导及突触传递，在G蛋白偶联受体蛋白信号转导途径中有一定的作用，并且有负调控腺苷酸环化酶的作用，为膜性蛋白，在胞膜、胞浆中表达。
促代谢型谷氨酸受体2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 细胞凋亡 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid