甘氨酸转运蛋白1抗体
规格：1尘驳/1尘濒
英文名： Glyt1
别名： SLC6A9; glycine transporter 1; Glyt 1; GlyT-1 antibodyGlyT1; SC6A9_HUMAN; sodium and chloride dependent glycine transporter 1; Sodium- and chloride-dependent glycine transporter 1; Solute carrier fami
分子量： 78kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Glyt1/SL
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit,
细胞定位：细胞膜
甘氨酸转运蛋白1抗体产物介绍：background: Na+/Cl- dependent neurotransmitter transporters are a superfamily of transmembrane proteins that contain 12 membrane spanning regions (1). Specifically, the highly hydrophobic Na+/Cl- dependent glycine transporters (GlyT) are crucial for the termination of neurotransmission at glycinergic synapses (2,3). Two different GlyT genes encode GlyT2 and GlyT1, which exists as two isoforms produced by alternative splicing of the same gene located on human chromosome 1p31.3 (3,4). The GlyT1 gene may be an early marker of neural development and encodes glia-specific transporter proteins (3). Although GlyT1 and GlyT2 are both expressed in the brain and spinal cord甘氨酸转运蛋白1抗体, each shows a unique pattern of expression (3,5,6). GlyT1 is found only in the white matter of the CNS, whereas GlyT2 is found in the gray matter of the CNS as well as in macrophages and mast cells in peripheral tissues (3,5). The anatomic distribution of GlyT2 mRNA suggests that glycine may act as a supraspinal neurotransmitter and may function as a chemical messenger outside the CNS (5). Function: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in甘氨酸转运蛋白1抗体 NMDA receptor-mediated neurotransmission. Subcellular Location: Membrane. Tissue Specificity: Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain. Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily. Database links: Entrez Gene: 14664 Mouse Entrez Gene: 116509 Rat SwissProt: P28571 Mouse SwissProt: P28572 Rat Unigene: 244549 Mouse Unigene: 32110 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
甘氨酸转运蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 转运蛋白 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid