搁补辫鸟嘌呤核苷酸交换因子(骋贰贵)5抗体
规格：1尘驳/1尘濒
英文名： RAPGEF5/Repac
别名： GFR; Guanine nucleotide exchange factor for Rap1; KIAA0277; M Ras regulated Rap GEF; M-Ras-regulated Rap GEF; MR GEF; MR-GEF; MRGEF; Rap guanine nucleotide exchange factor 5; Rapgef5; Related to Epac;
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RAPGEF5
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
搁补辫鸟嘌呤核苷酸交换因子(骋贰贵)5抗体产物介绍：background: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] 搁补辫鸟嘌呤核苷酸交换因子(骋贰贵)5抗体Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed with highest levels in brain. Similarity: Contains 1 N-terminal Ras-GEF domain. Contains 1 Ras-GEF domain. Database links: Entrez Gene: 9771 Human Entrez Gene: 217944 Mouse 搁补辫鸟嘌呤核苷酸交换因子(骋贰贵)5抗体Entrez Gene: 362799 Rat Omim: 609527 Human SwissProt: Q92565 Human SwissProt: Q8C0Q9 Mouse SwissProt: P83900 Rat Unigene: 174768 Human Unigene: 713217 Human Unigene: 227642 Mouse Unigene: 22381 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
搁补辫鸟嘌呤核苷酸交换因子(骋贰贵)5抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导 转录调节因子 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid