搁补辫鸟嘌呤核苷酸交换因子2抗体
规格：1尘驳/1尘濒
英文名： RAPGEF2
别名： KIAA0313; Neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor 1; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ
分子量： 167kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RAPGEF2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
搁补辫鸟嘌呤核苷酸交换因子2抗体产物介绍：background: SummaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] Function: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP. Subunit: Interacts with MAGI2搁补辫鸟嘌呤核苷酸交换因子2抗体. Subcellular Location: Cell membrane (By similarity). Note=Associated with the synaptic plasma membrane Tissue Specificity: Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta. Post-translational modifications: Phosphorylation by PLK2 promotes its activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 搁补辫鸟嘌呤核苷酸交换因子2抗体cyclic nucleotide-binding domain. Contains 1 N-terminal Ras-GEF domain. Contains 1 PDZ (DHR) domain. Contains 1 Ras-associating domain. Contains 1 Ras-GEF domain. Database links: Entrez Gene: 9693 Human Omim: 609530 Human SwissProt: Q9Y4G8 Human Unigene: 723853 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
搁补辫鸟嘌呤核苷酸交换因子2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 G蛋白偶联受体 交换蛋白 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid