酪氨酸单氧化酶微管相关蛋白惭滨颁础尝抗体
规格：1尘驳/1尘濒
英文名： MICAL1
别名： Alternative namesCasL interacting molecule; MICA1_HUMAN; MICAL 1; MICAL; MICAL1; microtubule associated monoxygenase, calponin and LIM domain containing 1 antibody Molecule interacting with CasL prote
分子量： 119kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MICAL1 (
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep,
细胞定位：细胞浆
酪氨酸单氧化酶微管相关蛋白惭滨颁础尝抗体产物介绍：background: MICAL1 is a 1,067 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Expressed in kidney, thymus, spleen, lung and testis, MICAL1 interacts with the SH3 domain of Cas-L and, via this interaction, is thought to function as a cytoskeletal regulator that connects Cas-L to intermediate filaments. MICAL1 also interacts with Rab 1B, plexin-A3 and Vimentin, further regulating cytoskeletal events and possibly playing a role in axonal repulsion. Three isoforms of MICAL1 exist due to alternative splicing events. Function: Monooxygenase that酪氨酸单氧化酶微管相关蛋白惭滨颁础尝抗体 promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis 酪氨酸单氧化酶微管相关蛋白惭滨颁础尝抗体via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Subunit: Interacts with STK38 and STK38L (By similarity). Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Tissue Specificity: Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. Similarity: Belongs to the Mical family. Contains 1 CH (calponin-homology) domain. Contains 1 LIM zinc-binding domain. Database links: UniProtKB/Swiss-Prot: Q8TDZ2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
酪氨酸单氧化酶微管相关蛋白惭滨颁础尝抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid