钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体
规格：1尘驳/1尘濒
英文名： CADPS2
别名： Cadps2; Calcium-dependent activator protein for secretion 2; Calcium-dependent secretion activator 2; CAPS2; CAPS2_HUMAN.
分子量： 148kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CADPS2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体产物介绍：background: Calcium-dependent secretion activators (CAPS-1 and CAPS-2) are calcium-binding proteins that direct neurotransmitter and neuropeptide-filled vesicles to the cell membrane for secretory granule exocytosis. Both CAPS-1 and CAPS-2 are expressed primarily in the brain where they regulate the secretion of various substances. The CAPS proteins contain a PH domain that is essential for regulation of exocytosis, as well as regulation of phospholipid binding. Through their regulation of neurotrophin release from granule cells, CAPS proteins help to regulate cell fate during neuronal development. CAPS-1 is thought to regulate catecholamine release from neuronal cells, while CAPS-2 is thought to regulate release of both brain-derived neurotrophic factor and neurotrophin-3 from granule cells. Defects in the genes encoding CAPS-1 and CAPS-2 are implicated in impaired cerebral development and autism. Function: RelevanceCADPS2 (Ca2+-dependent activator protein for secretion) belongs to the CAPS/Cadps family and consists of two members, CAPS1 and CAPS2. Both members钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体 play an important role in secretory granule exocytosis. CADPS2 is involved in the release of two neurotrophins, brain-derived neurotrophic factor and neurotrophin-3, from parallel fibers of cerebellar granule cells. CAPS proteins are expressed predominantly in the brain. CADPS2 has been found in various brain regions including the olfactory bulb, cerebrum, hippocampal formation, thalamus, mesencephalic tegmentum, cerebellum, medulla and spinal cord. CADPS2 colocalizes with proteins related to exocytosis (VAMP and SNAP-25) and endocytosis (Dynamin I) in the cell soma and processes of the mesencephalic tegmentum and cerebellum. Subunit: Homodimer (By similarity). Interacts with the dopamine receptor DRD2. Subcellular Location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. 钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles. Tissue Specificity: Widely expressed. Expressed in all and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen. Post-translational modifications: Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 C2 domain. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 PH domain. Database links: UniProtKB/Swiss-Prot: Q86UW7.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid