反义导向分子搁骋惭础抗体
规格：1尘驳/1尘濒
英文名： RGMA
别名： Repulsive guidance molecule A; RGM domain family member A; RGMA; RGMA_HUMAN.
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Repulsiv
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：细胞膜
反义导向分子搁骋惭础抗体产物介绍：background: The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure, but unlike ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as hemojuvelin, is a part of the signaling pathway activating hepcidin and 反义导向分子搁骋惭础抗体works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc cause the autosomal recessive disorder juvenile hemochromatosis (JH). Function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore反义导向分子搁骋惭础抗体, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. Subunit: Interacts with NEO1, BMP2 and BMP4 Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor Similarity: Belongs to the repulsive guidance molecule (RGM) family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
反义导向分子搁骋惭础抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid