精神发育迟滞相关蛋白翱濒颈驳辞辫丑谤别苍颈苍-1抗体
规格：1尘驳/1尘濒
英文名： Oligophrenin 1
别名： Oligophrenin1; Oligophrenin-1; OPHN1_HUMAN.
分子量： 92kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from huamn Oligophr
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞膜
精神发育迟滞相关蛋白翱濒颈驳辞辫丑谤别苍颈苍-1抗体产物介绍：background: Ras p21 can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (1,2). Interaction of Ras p21 with GTPase activating protein (GAP) can increase the rate of hydrolysis of Ras p21-bound GTP by as much as 1000-fold (3). In mitogenically activated and tyrosine kinase-transformed cells, Ras GAP forms a complex with a protein designated p190 (4). At its amino terminus, p190 contains sequence motifs characteristic of all known GTPases, whereas the carboxy terminus contains sequences similar to those found in the Bcr gene product, n-chimerin and Rho GAP, all of which exhibit intrinsic GAP activity (4,5). Oligophrenein-1 is an additional protein with GTPase activating activity. Oligophrenein-1 is a RhoGAP protein that stimulates GTP hydrolysis of Rho 精神发育迟滞相关蛋白翱濒颈驳辞辫丑谤别苍颈苍-1抗体subfamily members and is involved in cell migration, morphogenesis and axon outgrowth (6). Function: Stimulates GTP hydrolysis of members of the Rho family. Could activates GTPase targets that are known to affect cell migration and outgrowth of axons and dendrites. Subunit: Interacts with HOMER1. Interacts with AMPA receptor complexes. Interacts with SH3GL2 (endophilin-A1) Subcellular Location: Cell junction, synapse. Cell projection, axon. Cell projection, dendritic spine. Note=Present in both presynaptic and postsynaptic sites Tissue Specificity:精神发育迟滞相关蛋白翱濒颈驳辞辫丑谤别苍颈苍-1抗体 Expressed in brain. DISEASE: Defects in OPHN1 are the cause of mental retardation X-linked OPHN1-related (MRXSO) [MIM:300486]; formerly designated MRX60. MRXSO is a syndromic mental retardation. Patients present mental retardation associated with cerebellar hypoplasia and distinctive facial dysmorphism. Similarity: Contains 1 PH domain. Contains 1 Rho-GAP domain. Gene ID: 4983 Database links: Entrez Gene: 4983 Human Omim: 300127 Human SwissProt: O60890 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
精神发育迟滞相关蛋白翱濒颈驳辞辫丑谤别苍颈苍-1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid