鸟嘌呤核苷酸交换因子贵础搁笔2抗体
规格：1尘驳/1尘濒
英文名： FARP2
别名： FARP 2; FERM; FGD1 related Cdc42 GEF; FIR; FRG; KIAA0793; PLEKHC3; RhoGEF and pleckstrin domain protein 2; FARP2_HUMAN.
分子量： 120kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FARP2 (6
交叉反应：Human, Mouse, Rat, Chicken, Horse,
细胞定位：
鸟嘌呤核苷酸交换因子贵础搁笔2抗体产物介绍：background: FARP2 is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from 鸟嘌呤核苷酸交换因子贵础搁笔2抗体plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism. Function: FARP2 is a Rho-guanine nucleotide exchange factor that activates RAC1. It plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Subunit: Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. 鸟嘌呤核苷酸交换因子贵础搁笔2抗体Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FERM domain. Contains 2 PH domains. Gene ID: 9855 Database links: Entrez Gene: 9855 Human Entrez Gene: 227377 Mouse SwissProt: O94887 Human SwissProt: Q91VS8 Mouse Unigene: 726316 Human Unigene: 243091 Mouse Unigene: 28761 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鸟嘌呤核苷酸交换因子贵础搁笔2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid