内皮细胞分化骋蛋白偶联受体8抗体
规格：1尘驳/1尘濒
英文名： EDG8
别名： EDG 8; Endothelial differentiation G protein coupled receptor 8; Endothelial differentiation G-protein-coupled receptor 8; Endothelial Differentiation Gene 8; Endothelial differentiation sphingolipid
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EDG8 (1-
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep,
细胞定位：细胞膜
内皮细胞分化骋蛋白偶联受体8抗体产物介绍：background: The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in 内皮细胞分化骋蛋白偶联受体8抗体cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through Gi/o proteins, which activate growth related pathways. Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. Subcellular Location: Cell membrane; Multi-pass membrane protein Tissue Specificity: Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes,内皮细胞分化骋蛋白偶联受体8抗体 placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 53637 Database links: Entrez Gene: 53637 Human Entrez Gene: 94226 Mouse Entrez Gene: 100141401 Pig Entrez Gene: 60399 Rat Omim: 605146 Human SwissProt: Q9H228 Human SwissProt: Q91X56 Mouse SwissProt: Q684M3 Pig SwissProt: Q9JKM5 Rat Unigene: 501561 Human Unigene: 190619 Mouse Unigene: 45601 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
内皮细胞分化骋蛋白偶联受体8抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-100 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 神经生物学 信号转导 G蛋白偶联受体 表观遗传学 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid