唐氏综合征细胞粘附分子抗体
规格：1尘驳/1尘濒
英文名： Dscam
别名： CHD2 42; CHD2 52; CHD2; Down syndrome cell adhesion molecule; DSCAM; DSCAM_HUMAN; human CHD2-52 down syndrome cell adhesion molecule 2, 9; OTTHUMP00000109193 2; SD11109p.
分子量： 220kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Dscam (3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
细胞定位：细胞膜 分泌型蛋白
唐氏综合征细胞粘附分子抗体产物介绍：background: DSCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is predominantly expressed in brain and contains six Fibronectin type-III domains and ten Ig-like C2-type domains. In mice, DSCAM is responsible for regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). In some cell types, DSCAM also mediates heteroneuronal self-avoidance, which is important for the regular spacing of cell bodies and the prevention of hyperfasciculation. In humans, two DSCAM isoforms exist due to alternative splicing. The long isoform (also known as CHD2-42) is a single pass type I membrane protein, while the short isoform (CHD2-52), which lacks the C-terminal transmembrane containing region (amino acids 1572-2012), is secreted. Function: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the 唐氏综合征细胞粘附分子抗体same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Subunit: Interacts with DCC; the interaction is abolished in response to NTN1 (By similarity). Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1唐氏综合征细胞粘附分子抗体 Interacts (via extracellular domain) with NTN1. Interacts (via cytoplasmic domain) with PAK1; the interaction is direct and enhanced in presence of RAC1. Interacts with RAC1; the interaction requires PAK1. Subcellular Location: Secreted and Cell membrane. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. Tissue Specificity: Primarily expressed in brain. Post-translational modifications: Phosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin. Similarity: Contains 6 fibronectin type-III domains. Contains 10 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 1826 Database links: Entrez Gene: 1826 Human Entrez Gene: 13508 Mouse Entrez Gene: 171119 Rat Omim: 602523 Human SwissProt: O60469 Human SwissProt: Q9ERC8 Mouse SwissProt: Q8VHZ8 Rat Unigene: 397800 Human Unigene: 24399 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
唐氏综合征细胞粘附分子抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid